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目錄
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招股説明書副刊
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GENERAL MATTERS
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| | | | S-1 | | |
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招股説明書補充摘要
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| | | | S-3 | | |
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RECENT DEVELOPMENTS
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| | | | S-3 | | |
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THE OFFERING
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| | | | S-4 | | |
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RISK FACTORS
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| | | | S-5 | | |
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流通股和借款資本變動
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| | | | S-31 | | |
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USE OF PROCEEDS
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| | | | S-32 | | |
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DIVIDEND POLICY
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| | | | S-33 | | |
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有關前瞻性陳述的警告
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| | | | S-34 | | |
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PRIOR SALES
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| | | | S-38 | | |
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成交價和成交量
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| | | | S-39 | | |
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匯率信息
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| | | | S-40 | | |
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針對美國持有者的某些重要的美國聯邦所得税考慮因素
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| | | | S-41 | | |
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PLAN OF DISTRIBUTION
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| | | | S-47 | | |
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民事責任的可執行性
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| | | | S-49 | | |
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LEGAL MATTERS
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| | | | S-50 | | |
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審計師、轉讓代理和登記員
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| | | | S-50 | | |
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通過引用併入的文檔
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| | | | S-51 | | |
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作為註冊聲明的一部分提交的文件
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| | | | S-53 | | |
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您可以在哪裏找到更多信息
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| | | | S-53 | | |
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法定撤銷權和撤銷權
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| | | | S-54 | | |
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執行鍼對外國人士或公司的判決
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| | | | S-54 | | |
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Bellus Health Inc.證書
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| | | | C-1 | | |
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ABOUT THIS PROSPECTUS
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| | | | 1 | | |
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財務信息
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| | | | 1 | | |
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其他信息
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| | | | 1 | | |
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通過引用併入的文檔
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| | | | 3 | | |
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作為美國註冊聲明的一部分提交的文件
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| | | | 5 | | |
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前瞻性陳述
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| | | | 6 | | |
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THE COMPANY
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| | | | 9 | | |
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RECENT DEVELOPMENTS
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| | | | 9 | | |
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BUSINESS OF THE COMPANY
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| | | | 10 | | |
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REGULATORY MATTERS
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| | | | 23 | | |
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合併資本化
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| | | | 36 | | |
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USE OF PROCEEDS
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| | | | 36 | | |
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SELLING SHAREHOLDERS
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| | | | 37 | | |
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PLAN OF DISTRIBUTION
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| | | | 38 | | |
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加拿大和美國聯邦所得税的某些考慮因素
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| | | | 39 | | |
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加拿大聯邦所得税的某些考慮因素
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| | | | 39 | | |
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針對美國持有者的某些重要的美國聯邦所得税考慮因素
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| | | | 43 | | |
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股本説明
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| | | | 49 | | |
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BOOK-BASED SYSTEM
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| | | | 50 | | |
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普通股成交價和成交量
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| | | | 50 | | |
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PRIOR SALES
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| | | | 50 | | |
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RISK FACTORS
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| | | | 51 | | |
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LEGAL MATTERS
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| | | | 77 | | |
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審計師、轉讓代理和登記員
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| | | | 77 | | |
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執行鍼對外國人士或公司的判決
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| | | | 77 | | |
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知名經驗豐富的發行商
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| | | | 78 | | |
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購買者的法定撤銷權和撤銷權
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| | | | 78 | | |
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公司證書
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| | | | C-1 | | |
簽發日期
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數量
已發行股份 |
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價格(每
普通股) |
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July 18, 2022
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16,540,541
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US$9.25
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July 28, 2022
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2,481,081
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US$9.25
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行使日期
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數量
已發行期權 |
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價格
(每個選項) |
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2021年11月10日
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180,000
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US$7.04
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2022年2月23日
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2,945,000
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US$7.01
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March 23, 2022
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390,000
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US$6.38
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May 11, 2022
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220,000
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US$7.85
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July 6, 2022
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200,000
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US$9.58
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2022年11月14日
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218,500
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US$9.00
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行使日期
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數量
已發行股份 |
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行權價格
(每股) |
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2021年12月14日
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25,000,000
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US$8.00
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2021年12月23日
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33,334
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Cdn$1.08
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2021年12月23日
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4,000
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Cdn$3.14
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2021年12月29日
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3,000,000
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US$8.00
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2022年1月10日
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4,111
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Cdn$1.80
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2022年1月11日
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3,000
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Cdn$1.80
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2022年2月17日
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5,667
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Cdn$3.78
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March 1, 2022
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118,520
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Cdn$1.80
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March 1, 2022
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86,720
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Cdn$1.80
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March 3, 2022
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20,833
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Cdn$1.80
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March 3, 2022
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11,111
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Cdn$1.08
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March 3, 2022
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16,666
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Cdn$1.26
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March 22, 2022
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87,442
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Cdn$1.80
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April 8, 2022
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2,072
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Cdn$3.14
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April 19, 2022
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1,301
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Cdn$3.58
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May 20, 2022
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23,490
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Cdn$1.26
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TSX
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NASDAQ COMPOSITE
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HIGH
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LOW
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VOLUME
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HIGH
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LOW
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VOLUME
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(CDN$)
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(CDN$)
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(#)
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(US$)
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(US$)
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(#)
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2021年11月
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| | | | 9.47 | | | | | | 6.91 | | | | | | 1,701,319 | | | | | | 7.65 | | | | | | 5.41 | | | | | | 23,184,217 | | |
2021年12月
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| | | | 12.59 | | | | | | 6.64 | | | | | | 3,968,455 | | | | | | 9.84 | | | | | | 5.18 | | | | | | 153,383,543 | | |
2022年1月
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| | | | 10.55 | | | | | | 6.30 | | | | | | 2,775,604 | | | | | | 8.21 | | | | | | 4.98 | | | | | | 22,294,330 | | |
2022年2月
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| | | | 9.40 | | | | | | 7.23 | | | | | | 2,357,964 | | | | | | 7.45 | | | | | | 5.61 | | | | | | 28,447,599 | | |
2022年3月
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| | | | 8.85 | | | | | | 7.00 | | | | | | 1,601,946 | | | | | | 7.11 | | | | | | 5.45 | | | | | | 10,156,932 | | |
2022年4月
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| | | | 11.29 | | | | | | 8.46 | | | | | | 2,040,624 | | | | | | 9.04 | | | | | | 6.76 | | | | | | 17,818,288 | | |
May 2022
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| | | | 11.68 | | | | | | 8.07 | | | | | | 3,830,869 | | | | | | 9.09 | | | | | | 6.35 | | | | | | 17,888,269 | | |
2022年6月
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| | | | 13.25 | | | | | | 9.18 | | | | | | 2,040,276 | | | | | | 10.28 | | | | | | 7.08 | | | | | | 19,689,433 | | |
2022年7月
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| | | | 14.46 | | | | | | 11.54 | | | | | | 3,312,894 | | | | | | 11.1 | | | | | | 8.76 | | | | | | 30,281,479 | | |
2022年8月
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| | | | 16.24 | | | | | | 12.07 | | | | | | 2,939,518 | | | | | | 12.69 | | | | | | 9.34 | | | | | | 18,371,441 | | |
2022年9月
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| | | | 16.01 | | | | | | 13.66 | | | | | | 7,778,310 | | | | | | 12.23 | | | | | | 10.07 | | | | | | 13,608,956 | | |
2022年10月
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| | | | 14.94 | | | | | | 12.31 | | | | | | 1,956,180 | | | | | | 10.95 | | | | | | 8.86 | | | | | | 10,510,242 | | |
2022年11月(至11月11日)
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| | | | 12.74 | | | | | | 11.50 | | | | | | 1,666,518 | | | | | | 9.43 | | | | | | 8.45 | | | | | | 5,958,597 | | |
(加元)
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截至的年度
十二月三十一日, 2021 |
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這一時期的最高利率
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1.2942
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期間的最低利率
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1.2040
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期間的平均匯率(1)
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1.2535
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期末匯率
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1.2678
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(加元)
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十一月
2022 |
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十月
2022 |
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九月
2022 |
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八月
2022 |
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七月
2022 |
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六月
2022 |
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可能
2022 |
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這段時間的最高水平
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1.3749
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1.3856
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1.3726
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1.3111
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1.3138
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1.3035
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1.3039
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這段時間的低點
|
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1.3378
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1.3547
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1.2980
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1.2753
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1.2824
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1.2540
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1.2648
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(Signed) ROBERTO BELLINI
總裁與首席執行官 |
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(Signed) RAMZI BENAMAR
首席財務官 |
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(Signed) FRANCESCO BELLINI
董事 |
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(Signed) PIERRE LAROCHELLE
董事 |
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ABOUT THIS PROSPECTUS
|
| | | | 1 | | |
|
財務信息
|
| | | | 1 | | |
|
其他信息
|
| | | | 1 | | |
|
通過引用併入的文檔
|
| | | | 3 | | |
|
作為美國註冊聲明的一部分提交的文件
|
| | | | 5 | | |
|
前瞻性陳述
|
| | | | 6 | | |
|
THE COMPANY
|
| | | | 9 | | |
|
RECENT DEVELOPMENTS
|
| | | | 9 | | |
|
BUSINESS OF THE COMPANY
|
| | | | 10 | | |
|
REGULATORY MATTERS
|
| | | | 23 | | |
|
合併資本化
|
| | | | 36 | | |
|
USE OF PROCEEDS
|
| | | | 36 | | |
|
SELLING SHAREHOLDERS
|
| | | | 37 | | |
|
PLAN OF DISTRIBUTION
|
| | | | 38 | | |
|
加拿大和美國聯邦所得税的某些考慮因素
|
| | | | 39 | | |
|
加拿大聯邦所得税的某些考慮因素
|
| | | | 39 | | |
|
針對美國持有者的某些重要的美國聯邦所得税考慮因素
|
| | | | 43 | | |
|
股本説明
|
| | | | 49 | | |
|
BOOK-BASED SYSTEM
|
| | | | 50 | | |
|
普通股成交價和成交量
|
| | | | 50 | | |
|
PRIOR SALES
|
| | | | 50 | | |
|
RISK FACTORS
|
| | | | 51 | | |
|
LEGAL MATTERS
|
| | | | 77 | | |
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審計師、轉讓代理和登記員
|
| | | | 77 | | |
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執行鍼對外國人士或公司的判決
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| | | | 77 | | |
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知名經驗豐富的發行商
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| | | | 78 | | |
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購買者的法定撤銷權和撤銷權
|
| | | | 78 | | |
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公司證書
|
| | | | C-1 | | |
所有參與者 - 意向治療患者(N=67)
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DOSE
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PLACEBO-
ADJUSTED REDUCTION IN AWAKE COUGH FREQUENCY |
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P-VALUE
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25 mg BID
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| | | | -11% | | | | | | p=0.14 | | |
50 mg BID
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| | | | -6% | | | | | | p=0.46 | | |
100 mg BID
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| | | | -8% | | | | | | p=0.41 | | |
200 mg BID
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| | | | -17% | | | | | | p=0.09 | | |
預先指定的分組 - 參與者,清醒咳嗽頻率為≥20次/小時(n=54)
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DOSE
|
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PLACEBO-
ADJUSTED REDUCTION IN AWAKE COUGH FREQUENCY |
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P-VALUE
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25 mg BID
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| | | | -20% | | | | | | p=0.0010 | | |
50 mg BID
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| | | | -18% | | | | | | p=0.0186 | | |
100 mg BID
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| | | | -19% | | | | | | p=0.0320 | | |
200 mg BID
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| | | | -27% | | | | | | p=0.0026 | | |
清醒咳嗽頻率等於或高於基線的預先指定的分組 - 參與者
MEDIAN (≥ 32.4 COUGHS/HOUR; N=34) |
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DOSE
|
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PLACEBO-
ADJUSTED REDUCTION IN AWAKE COUGH FREQUENCY |
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P-VALUE
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25 mg BID
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| | | | -28% | | | | | | p=0.0005 | | |
50 mg BID
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| | | | -28% | | | | | | p=0.0003 | | |
100 mg BID
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| | | | -30% | | | | | | p=0.0014 | | |
200 mg BID
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| | | | -32% | | | | | | p=0.0006 | | |
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(Signed) R奧貝託·貝裏尼
總裁和首席執行官 |
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(Signed) R阿姆齊·貝納馬爾
首席財務官 |
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代表董事會
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(Signed) Dr F貝裏尼
Director |
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(Signed) P艾爾·拉羅切爾
Director |
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