Www.investorvote.com/supn 第1步：轉至www.investorvote.com/supn。 第2步：單擊右側圖標查看會議材料。 第3步：返回investorvote.com窗口並按照屏幕上的説明登錄。 在線 轉至www.investorvote.com/supn或掃描 二維碼-登錄詳細信息位於下面的陰影欄中。 Supernus PharmPharmticals，Inc. 股東大會通知 03MW5B + + 有關將於2022年6月17日舉行的Supernus PharmPharmticals，Inc.股東大會代理材料供應的重要通知 根據美國證券交易委員會的規定，您將收到此通知，年度股東大會的代理材料可在互聯網上獲得。請按照下面的説明查看材料並在線投票，或 索取副本。年度會議的表決項目和地點在背面。您的投票很重要！ 此通信僅概述了Internet上向您提供的更完整的代理材料。 我們鼓勵您在投票前訪問並查看代理材料中包含的所有重要信息。2022 委託書、年度股東報告和年度大會通知可在以下網址獲得： 獲取代理材料副本-如果您想收到代理材料的紙質副本，則必須 索取一份。你索要複印件是不收費的。請在2022年6月6日或之前，按照背面的説明提出您的請求，以便於及時交付。 2不易在線訪問-查看您的代理材料並投票。 當您在線時, 您還可以通過同意接收未來材料的電子遞送來改善環境。 第4步：按照每個屏幕上的説明為您的遞送首選項進行選擇。 第5步：投票您的股份。 MMMMMMMMM mr A示例 指定(如果有) 添加1 添加2 添加3 添加4 添加5 添加6 認可_line__SACKPACK_ 1234 5678 9012 345 C 1234567890 COY 000004 mm mm

Here’s how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. — Internet – Go to www.investorvote.com/SUPN. — Phone – Call us free of charge at 1-866-641-4276. — Email – Send an email to investorvote@computershare.com with “Proxy Materials Supernus Pharmaceuticals, Inc.” in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, requests for a paper copy of proxy materials must be received by June 6, 2022. The 2022 Annual Meeting of Stockholders of Supernus Pharmaceuticals, Inc. will be held on June 17, 2022 at 10:00 A.M. Eastern Daylight Time, virtually via the Internet at meetnow.global/M59NRDM. To access the virtual meeting, you must have the information that is printed in the shaded bar located on the reverse side of this form. Proposals to be voted on at the meeting are listed below along with the Board of Directors’ recommendations. The Board of Directors recommend a vote FOR all the nominees listed and FOR Proposals 2 and 3: 1. to elect two (2) directors to hold office for the ensuing three years and until their successors have been duly elected and qualified; 01 - Carrolee Barlow, M.D., Ph.D. 02 - Jack A. Khattar 2. to ratify the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022; 3. to approve, on a non-binding basis, the compensation paid to our named executive officers; and 4. to transact such other business as may properly come before the Annual Meeting or any adjournment or adjournments thereof PLEASE NOTE – YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. Stockholder Meeting Notice