股東周年大會 ExScience a plc(“本公司”) 股東周年大會編號： 美國存託憑證編號： 美國存托股份備案日期： 會議詳情： 會議議程： 託管協議： 託管證券： 託管證券： 上述根據存託協議(“美國存託憑證”)發行的美國存托股份(“美國存托股份”)的簽名持有人，截至美國存托股份備案日期，確認已收到託管人的年度股東大會通知副本，並特此授權和指示託管人安排在會議(及其任何延期或延期)上按照本協議背面顯示的方式對ADS所代表的已交存證券進行表決。所有未在本文中定義的大寫術語應具有《存款協議》中賦予該術語的含義。本文和任何相關材料中包含的有關會議和美國存托股份投票指示的信息可能會因情況變化(例如，會議延期或取消，以及會議舉行方式的變化)而在本協議日期後發生變化。公司僅打算在其網站https://investors.exscientia.ai/financials-and-filings/Annual-General-Meeting.上宣佈任何更改和更新我們鼓勵您 查看參考公司網站，以獲取有關會議和美國存托股份投票指令的任何更新信息，因為預計不會通過郵件或電子郵件向您分發任何其他信息。 投票指令只能針對代表整數個已交存證券的數量的美國存託憑證。在按託管人指定的方式及時收到截至美國存托股份投票記錄日期的美國存託憑證指示後，託管人應在可行的範圍內並在適用法律允許的範圍內盡最大努力, 根據《存託協議》、《公司組織章程》和《託管證券》的規定，託管人和託管人在任何情況下都不得投票(除非《存託協議》另有規定)，託管人和託管人在任何情況下都不得對該持有人的美國存託憑證所代表的託管證券(親自或委託)進行表決。託管人和託管人均不得投票，且託管人和託管人均不得投票。試圖行使投票權，或以任何 方式利用美國存託憑證所代表的存入證券的法定人數或其他目的，除非根據並按照及時從持有人那裏收到的投票指示 或存款協議中的其他預期。如果託管人及時收到持有人的投票指示，而該指示未能具體説明託管人對該持有人的美國存託憑證所代表的已交存證券進行表決的方式，則託管人將視為該持有人已指示該持有人對此類表決指示中所列的項目投贊成票。 請在投票指示的背面註明如何對已交存的證券進行表決。 必須在投票指示的反面註明、簽署並按時退回投票指示，才能進行統計。以下籤署人向保管人和公司表示，簽署人已獲得正式授權，可以發出投票指示。 投票指示必須在5月12日上午10：00(東部夏令時)之前在指定地址簽署、填寫並收到, 2022年將採取行動。 2022年美國存托股份投票指示 30223G102。 30223G995。 2022年4月118。 股東周年大會將於2022年5月18日(星期三)上午9：00舉行。(英國夏季時間)在英國牛津OX1 4AU商業街71號馬格達倫學院舉行(會議)。 請參閲公司年度股東大會通知和其他有關文件 截至2021年10月5日的公司website： https://investors.exscientia.ai/financials-and-filings/Annual-General-Meeting Citibank，N.A.存款協議。 普通股，名義價值每股0.0005 GB，公司。 花旗銀行，N.A.(倫敦)。 。 ExScience a plc

Signature 1 - Please keep signature within the line Signature 2 - Please keep signature within the line Date (mm/dd/yyyy) If this Voting Instructions Card is signed and timely returned to the Depositary but no specific direction as to voting is marked above as to an issue, the undersigned shall be deemed to have directed the Depositary to give voting instructions “FOR” the unmarked issue. If these Voting Instructions are signed and timely returned to the Depositary but multiple specific directions as to voting are marked above as to an issue, the undersigned shall be deemed to have directed the Depositary to give an “ABSTAIN” voting instruction for such issue. Please be sure to sign and date this Voting Instructions Card. Please sign your name to the Voting Instructions exactly as printed. When signing in a fiduciary or representative capacity, give full title as such. Where more than one owner, each MUST sign. A Voting Instructions Card executed by a corporation should be in the full name of a duly authorized officer with full title as such. Authorized Signatures - Sign Here - This section must be completed for your instructions to be executed. B For Against Abstain Resolution 1 Ordinary Resolutions Resolution 2 Resolution 3 Resolution 4 Resolution 5 For Against Abstain Resolution 6 Resolution 7 Resolution 8 Issues Exscientia plc A RESOLUTIONS Ordinary Resolutions 1. To receive and adopt the accounts of the Company for the year ended 31 December 2021 together with the reports of the Directors and the auditors thereon (the “2021 Annual Report and Accounts”). 2. To approve the Directors’ Remuneration Report (other than the Directors’ Remuneration Policy referred to in Resolution 3 below), as set out in the 2021 Annual Report and Accounts, for the financial year ended 31 December 2021. 3. To approve the Directors’ Remuneration Policy set out on pages 58 to 70 within the Directors’ Remuneration Report contained in the 2021 Annual Report and Accounts, such Remuneration Policy to take effect immediately after the end of the Annual General Meeting. 4. To re-appoint Robert Ghenchev as a Director of the Company who is retiring in accordance with Article 81.2 of the Company’s articles of association and, being eligible, is offering himself for re-appointment. 5. To re-appoint PricewaterhouseCoopers LLP as the Company’s auditors to act as such until the conclusion of the next annual general meeting of the Company at which the requirements of section 437 of the Companies Act 2006 (the “Act”) are complied with. 6. To authorise the Directors of the Company to determine the auditors’ remuneration. 7. To approve: (i) the form of share repurchase contracts (the “Share Repurchase Contracts”) for the purchase by the Company of such number of its ordinary shares of £0.0005 each (including ordinary shares represented by American Depositary Shares), at such prices as may be agreed pursuant to the terms of a Share Repurchase Contract, and the Company be and is hereby authorised to enter into any Share Repurchase Contract negotiated and agreed with a Counterparty (as defined in (ii)); and (ii) the counterparties with whom the Company may enter into a Share Repurchase Contract, being the counterparties (or their subsidiaries or affiliates from time to time) included in this document (the “Counterparties”), provided that, unless previously renewed, varied, or revoked by the Company at a general meeting, this authority shall expire on the fifth anniversary of the Annual General Meeting. 8. To approve the form of the deferred shares repurchase contract (the “Deferred Shares Repurchase Contract”) for the purchase by the Company of its deferred shares of £0.01 each, and the Company be and is hereby authorised to enter into the Deferred Share Repurchase Contract (such authority to expire on 17 May 2027). The Board of Directors recommends a FOR vote for all resolutions.