通過埃德加

2017年月一日

美國證券交易委員會

公司財務部

東經F街100號

華盛頓特區20549

表格上登記聲明的加速請求S-3

文件編號333-221491

女士們先生們：

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), CRISPR Therapeutics AG (the “Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to December 4, 2017, at 4:01 pm Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time.在提出這一加速請求時，該公司承認它知道它根據該法案所承擔的責任。

如果您對此請求有任何疑問，請與Goodwin Procter LLP公司的Robert Puopolo聯繫，電話：(617) 570-1393.