展示 10.1

修訂後的票據

對於 收到的價值，Orgenesis Maryland, LLC，一家馬里蘭州有限責任公司（”借款人”）和全資子公司 Orgenesis Inc. (”orgenesis”），特此承諾按雅各布·薩菲爾或其繼任者或受讓人的命令付款 （”持有者”），本金爲一百萬美元（合1,000,000美元），按本修訂和重述中規定的方式計算 期票（這個”注意”).

1. 主要債務人應於2024年12月31日或如下文4節中所述的情況下，全額支付給持有人全部未償本金餘額，並支付在此項下到期的所有其他款項，如果未按照本協議所要求或允許提前支付。

2. 利息利息將按照年利率百分之十（10%）計息，包括現有票據（本合同第9.6節所定義）上產生的利息。利息應按實際逝去天數以365天爲一年的基礎計算。

3. 預付款本票的未償本金餘額可以隨時全額或部分以現金方式提前償還，不收取溢價、罰金或折扣。

4. 償還如果借款人、其母公司orgenesis或orgenesis的任何其他子公司在本票據日期之後進行交易或系列相關交易，根據此交易，借款人、orgenesis或orgenesis的任何子公司發行和出售其股權證券，並使其總收益達到至少1500萬美元，持票人可以要求借據的全部未償本金和所有應計未付利息全額償還。

5. 權證作爲簽訂本票項的部分對價，Orgenesis將於上述日期向持有人發行五年期認股權，以購買Orgenesis普通股的累計數量爲970,873股，初始行權價格爲每股1.03美元，形式如附件所示。 附錄 A 如果借款人未能按照本票第1條的規定及時支付到期款項，Orgenesis將向持有人發行額外的五年期認股權，以購買Orgenesis普通股的累計數量爲970,873股，初始行權價格爲每股1.03美元，形式如附件所示。 附錄 A 現有信貸協議第10.14條的規定已經納入本協議並適用於本協議。

6. 借款人的陳述和保證。. 借款人在簽署本票之日向持票人作出以下陳述和保證：

6.1 根據授權借款方聲明和保證：（i）其執行和交付本票據，並根據本票據的交易進行交付的行爲已經得到了所有必要的授權。（ii）本票據已經由借款方合法有效地執行和交付，並構成借款方的有效和有約束力的義務，依據其條款可強制執行。

6.2 沒有衝突。借款人執行、交付和履行本借據，並且借款人完成本借據所涉及的交易，不會：(i)與或違反借款人的組織或章程文件的任何規定衝突，或(ii)與或違反任何協議、法律、規則、法規、命令、判決、禁令、法令或其他法院或政府機構的限制，這些限制會影響借款人履行本借據項下的義務。

7. 持有人的陳述和保證。持有人特此向借款人作出以下陳述和保證，即在簽署本票當日：

7.1 因授權證券持有人聲明並保證（i）其簽署和交付本票據及根據本處所載交易的實施已經得到其所需的一切必要授權行動的有效授權；（ii）該持票人已經恪守並交付了本票據，並構成持票人的有效和有約束力的義務，並可根據其條款對其執行。

7.2 沒有衝突。持有人執行、交付和履行本票據的行爲，並根據本票據進行的交易不會：（i）與持有人的組織或憲章文件的任何規定衝突或違反，或（ii）與任何協議、法律、規則、法規、命令、判決、禁令、法院或政府機構的任何限制衝突或違反，這些將會干擾持有人履行其在本票據項下的義務。

7.3 認可投資者通過簽名，持有人特此聲明和保證其是根據1933年的證券法修訂案第501(a)條規定在D類規定下發布的條例中定義的"認可投資者"。

8. 不履行責任的事件任何下列行爲、情況、事件或發生將構成本協議下的違約事件（以下簡稱“違約事件”):

8.1 借款人未能按照本協議支付到期本金或利息，並在收到持有人提供的通知後的十五天內未能解決該違約。

8.2 若借款人違反本借據中的任何協議，並在持有人提供通知後15天內未能解決該違約行爲。

8.3 (i) 借款人自願在美國破產法典（「破產法典」）下提起破產案件，或任何現行或今後生效的外國、聯邦或州的破產、無力清償或其他類似法律，或(ii) 借款人同意在無償破產或類似案件中獲得救濟令，或同意將無償案件轉爲自願案件，根據該法律的任何條款，或(iii) 借款人同意委任，或接管，或全部或實質性部分財產的接收人，託管人或其他保管人，或(iv) 借款人進行任何債權人受益的轉讓，或(v) 借款人書面承認其無法按約到期償還債務，或出現其他無力清償的情況；或破產法典）或任何外國、聯邦或州的破產、無力清償或其他類似法律現在或將來生效的，或（ii）借款人同意或掌握進入強制破產申請的命令，或將無償破產案件轉變爲自願案件的命令，根據其法律，或（iii）借款人同意的，或全部或其實質財產的保管人，受益人或其他保管人，抵押品，或（iv）借款人讓渡任何債權人受益，或（v）借款人書面承認其負債能力不足以按照債務到期的要求償還其債務或以其他方式不可在償還其債務。產生債務的情況

8.4 （i）在破產法案或任何適用的國內外、聯邦或州破產、無力償付或其他類似法律下，法院對借款人作出強制執行的裁決或命令，且該裁決或命令在進入之日起60天內未被暫停或解除，或（ii）法院對借款人或其全部或大部分財產任命接管人、清算人、扣押人、受託人、保管人或其他具有類似權限的人作出裁決或命令。

8.5 借款人或orgenesis在本註釋以外的一項或多項重要義務上違約或未履行，並且在收到有關該違約或未履行的書面通知後五（5）天內未能糾正該違約或未履行。

9. Remedies.

9.1 Remedies. In the event of an occurrence of any Event of Default, or at any time thereafter until such Event of Default is cured or waived to the written satisfaction of the Holder, the Holder may by notice in writing to the Borrower declare the entire principal amount of this Note, together with all other amounts owing hereunder, to be immediately due and payable without presentment, demand, protest, notice of protest or other notice of dishonor of any kind, all of which are waived by the Borrower; provided, that upon the occurrence of an Event of Default under Section 8.3, the entire unpaid principal amount of this Note then outstanding and all interest accrued and unpaid thereon will be immediately due and payable without presentment, demand, protest or notice of any kind. The Borrower agrees to pay on demand all reasonable costs and expenses, including attorney fees, incurred by the Holder in connection with the collection of this Note.

9.2 No Waiver; Remedies Cumulative. No failure or delay on the part of the Holder in exercising any right, power or remedy under this Note shall operate as a waiver thereof; nor shall any single or partial exercise of any such right, power or remedy preclude any other or further exercise thereof or the exercise of any other right, power or remedy under this Note. The remedies herein are cumulative and not exclusive of any remedies provided by law.

10. General.

10.1 Governing Law and Jurisdiction. This Note and the obligations of the parties hereunder will be construed and enforced in accordance with the laws of the State of New York.

10.2 Successors and Assigns. The rights and obligations of the Borrower and the Holder of this Note shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees. The Borrower may not assign this Note, in whole or in part, without the written consent of the Holder. The Holder may not assign this Note, in whole or in part, without the written consent of the Borrower.

10.3 Waiver. No waiver, forbearance, failure or delay by the Holder in exercising, or the exercise or beginning of exercise by the Holder of, any right, power or remedy, simultaneously or later, shall not preclude the further, simultaneous or later exercise thereof, and every right, power or remedy of the Holder shall continue in full force and effect until such right, power or remedy is specifically waived in a writing executed by the Holder.

10.4 Entire Agreement. This Note contains the entire agreement between the parties with respect to the subject matter hereof, and supersedes every course of dealing, other conduct, oral agreement or representation previously made by the parties. In the event that any court of competent jurisdiction shall determine that any provision, or portion thereof, contained in this Note shall be unenforceable in any respect, then such provision shall be deemed limited to the extent that such court deems it enforceable, and the remaining provisions of this Note shall nevertheless remain in full force and effect.

10.5 Notices. All notices and other communications given or made pursuant to this Note shall be in writing and shall be deemed effectively given upon the earlier of actual receipt or: (a) personal delivery to the party to be notified, (b) when sent, if sent by electronic mail or facsimile during normal business hours of the recipient, and if not sent during normal business hours, then on the recipient’s next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) business day after deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the respective parties at their address as set forth on their signature pages to this Note, or to such e-mail address, or address as subsequently modified by written notice given in accordance with this Section 9.5.

10.6 Amendment and Restatement. This Promissory Note amends and restates that certain Promissory Note in the principal amount of $250,000 issued to the Holder by the Borrower on June 26, 2024 (the “Existing Note”) in its entirety. Upon the issuance of this Note, the Existing Note shall be deemed superseded by this Note without any further action by the Holder or the Borrower. The indebtedness evidenced by the Existing Note is continuing indebtedness, and nothing in this Note shall be deemed to constitute a payment, settlement or novation of the Existing Note. All of the obligations of the Borrower from and after execution and delivery of this Note by the Borrower, continue in full force and effect as set forth herein.

10.7 Jury Trial Waiver. THE BORROWER AND THE HOLDER KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVE ANY RIGHT THEY MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO ANY LITIGATION ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS NOTE OR ANY COURSE OF CONDUCT, COURSE OF DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN) OR ACTIONS OF THE OTHER PARTY HERETO.

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IN WITNESS WHEREOF, this Amended and Restated Promissory Note has been duly executed by the Borrower as of the day and year first above written.

ORGENESIS MARYLAND, LLC

Accepted and agreed as of the day and year first above written.

Email:

Address for Notices:

Accepted and agreed as of the day and year first above written.

ORGENESIS INC.

Email:

Address for Notices:

Exhibit A

Form of Warrant