Pfizer Starts Early-Stage Study Of Oral Antiviral COVID-19 Drug
Pfizer Starts Early-Stage Study Of Oral Antiviral COVID-19 Drug
輝瑞公司開始口服抗病毒新冠肺炎藥物的早期研究
Pfizer Inc (NYSE: PFE) has started an early-stage U.S. trial of an oral COVID-19 antiviral therapy, dubbed as PF-07321332.
- The drugmaker, which developed the first authorized COVID-19 vaccine in the U.S. with Germany's BioNTech SE (NASDAQ: BNTX), said the antiviral candidate showed potent activity against SARS-CoV-2 in lab studies.
- The Phase 1 study progressed to multiple ascending doses after completing the dosing of single ascending doses in healthy adults.
- PF-07321332 is a protease inhibitor that prevents the virus from replicating in cells.
- The company is also studying an intravenously administered antiviral candidate in an early-stage trial in hospitalized COVID-19 patients.
- Pfizer's candidate is behind two other oral antiviral therapies, which are in mid-stage trials:
- Molnupiravir - in development by Merck & Co (NYSE: MRK) with Ridgeback Bio. Recent interim data showed that the antiviral significantly reduced the infectious virus in COVID-19 patients after five treatment days.
- Roche Holdings AG (OTC:RHHBY) and Atea Pharmaceuticals Inc (NASDAQ: AVIR) are developing AT-527 in mild or moderate COVID-19 patients in an outpatient setting. The first patient was dosed in February.
- Gilead Sciences' remdesivir is currently the only FDA-approved drug for the treatment of COVID-19.
- The FDA granted an emergency authorization to intravenous therapies from Eli Lilly bamlanivimab alone and in combination with etesevimab, and a combination therapy from Regeneron.
- Price Action: PFE shares are trading 0.97% lower at $35.65 in market hours on the last check Tuesday.
Pfizer Inc (NYSE: PFE) has started an early-stage U.S. trial of an oral COVID-19 antiviral therapy, dubbed as PF-07321332.
輝瑞公司(紐約證券交易所代碼:PFE)已經開始在美國進行名為PF-07321332的口服新冠肺炎抗病毒療法的早期試驗。
- The drugmaker, which developed the first authorized COVID-19 vaccine in the U.S. with Germany's BioNTech SE (NASDAQ: BNTX), said the antiviral candidate showed potent activity against SARS-CoV-2 in lab studies.
- The Phase 1 study progressed to multiple ascending doses after completing the dosing of single ascending doses in healthy adults.
- PF-07321332 is a protease inhibitor that prevents the virus from replicating in cells.
- The company is also studying an intravenously administered antiviral candidate in an early-stage trial in hospitalized COVID-19 patients.
- Pfizer's candidate is behind two other oral antiviral therapies, which are in mid-stage trials:
- Molnupiravir - in development by Merck & Co (NYSE: MRK) with Ridgeback Bio. Recent interim data showed that the antiviral significantly reduced the infectious virus in COVID-19 patients after five treatment days.
- Roche Holdings AG (OTC:RHHBY) and Atea Pharmaceuticals Inc (NASDAQ: AVIR) are developing AT-527 in mild or moderate COVID-19 patients in an outpatient setting. The first patient was dosed in February.
- Gilead Sciences' remdesivir is currently the only FDA-approved drug for the treatment of COVID-19.
- The FDA granted an emergency authorization to intravenous therapies from Eli Lilly bamlanivimab alone and in combination with etesevimab, and a combination therapy from Regeneron.
- Price Action: PFE shares are trading 0.97% lower at $35.65 in market hours on the last check Tuesday.
- 這家制藥商與德國生物科技公司(納斯達克股票代碼:BNTX)合作開發了美國第一個授權的新冠肺炎疫苗,該公司表示,這種抗病毒候選藥物在實驗室研究中顯示出對SARS-CoV-2的強大活性。
- 第一階段研究在健康成年人完成單次遞增劑量後進行到多個遞增劑量。
- PF-07321332是一種蛋白酶抑制劑,可以阻止病毒在細胞內複製。
- 該公司還在研究一種靜脈注射的抗病毒候選藥物,用於住院的新冠肺炎患者的早期試驗。
- 輝瑞的候選人是另外兩種口服抗病毒療法的幕後推手,這兩種療法正在進行中期試驗:
- Molnupiravir-由默克公司(紐約證券交易所代碼:MRK)與Ridgeback Bio共同開發。最近的中期數據顯示,抗病毒藥物在治療5天后顯著降低了新冠肺炎患者的感染性病毒。
- 羅氏控股公司(場外交易代碼:RHHBY)和ATEA制藥公司(納斯達克市場代碼:AVIR)正在門診環境下為輕度或中度新冠肺炎患者開發AT-527型藥物。第一名患者在2月份接受了藥物治療。
- 吉利德科學公司的瑞德維韋目前是美國食品和藥物管理局批准的唯一一種治療新冠肺炎的藥物。
- FDA批准了禮來公司Bamlanivimab單獨和與etesevimab聯合使用的靜脈治療,以及Regeneron的聯合治療。
- 價格行動:在週二的最後一次檢查中,PFE股價在市場時段下跌0.97%,至35.65美元。
譯文內容由第三人軟體翻譯。
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