Kazia Therapeutics Licenses Cantrixil To Oasmia Pharmaceutical For Ovarian Cancer
Kazia Therapeutics Licenses Cantrixil To Oasmia Pharmaceutical For Ovarian Cancer
Kazia治療公司授權Cantrixil為治療卵巢癌的Oasmia製藥公司
Kazia Therapeutics Ltd (NASDAQ: KZIA) has entered an exclusive worldwide licensing agreement with Oasmia Pharmaceutical AB (OTC:OASMY) for Cantrixil under development the treatment of ovarian cancer.
- The agreement will see Sweden-based Oasmia assume exclusive worldwide rights to develop and commercialize Cantrixil for all indications, with an initial focus on ovarian cancer.
- Oasmia's lead product, Apealea (paclitaxel micellar), is approved in Europe for adult patients with the first relapse of platinum-sensitive epithelial ovarian cancer, primary peritoneal cancer, and fallopian tube cancer, and is in late-stage development in the U.S.
- Oasmia expects to commence a Phase 2 study of Cantrixil in ovarian cancer in 2022.
- Under the terms of the agreement, Oasmia will make an upfront payment of $4 million to Kazia, with contingent milestone payments of up to $42 million and double-digit royalties on commercial sales.
- Cantrixil is a proprietary formulation of the potent and selective third-generation benzopyran, TRX-E-002-1, that targets the entire spectrum of cancer cells, including chemotherapy-resistant tumor-initiating cells (cancer stem cells) thought to be responsible for disease relapse.
- In December last year, Kazia announced a Phase 1 study's top-line results and determined the maximum tolerated dose of Cantrixil to be 5 mg/kg.
- Price Action: KZIA closed 3.9% lower at 9.9 on Friday.
- 根據這項協議,總部位於瑞典的Oasmia公司將在全球範圍內獨家開發和商業化Cantrixil的所有適應症,最初的重點是卵巢癌。
- Oasmia的主導產品Apealea(紫杉醇膠束)在歐洲被批准用於對鉑敏感的上皮性卵巢癌、原發性腹膜癌和輸卵管癌首次復發的成年患者,並在美國處於後期開發階段。
- Oasmia預計將在2022年開始Cantrixil治療卵巢癌的第二階段研究。
- 根據協議條款,Oasmia將向Kazia預付400萬美元,或有里程碑付款最高可達4200萬美元,商業銷售的特許權使用費將達到兩位數。
- Cantrixil是一種有效和選擇性的第三代苯並吡喃TRX-E-002-1的專利配方,它針對整個癌細胞譜,包括被認為導致疾病復發的化療耐藥腫瘤啟動細胞(癌症幹細胞)。
- 去年12月,卡齊亞宣佈一項第一階段研究的主要結果,並確定Cantrixil的最大耐受量為5毫克/公斤。
- 價格行動:KZIA週五收低3.9%,報9.9。
譯文內容由第三人軟體翻譯。
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