U.S. competitiveness takes center stage in 2025 with four key investment themes—energy independence, defense innovation, infrastructure, and automation—poised to bolster portfolio growth. Global X's 2025 Investment Outlook, led by Scott Helfstein, highlights these transformative trends as critical drivers of resilience in the coming year.

Infrastructure Gets A Glow-Up

America's infrastructure renaissance is going full throttle, with $700 billion in spending set to energize construction, equipment, and materials companies. This may bode well for investors in the Industrial Select Sector SPDR Fund (NYSE:XLI).

These stalwarts of the old economy are reinventing themselves with cutting-edge tech to expand margins—all while trading at attractive valuations compared to the broader S&P 500.

The Defense Play: Beyond Jets & Ships

Global tensions are driving a pivot from traditional defense platforms to high-tech solutions like AI-driven drones and cybersecurity systems.

Palantir Technologies Inc's (NASDAQ:PLTR) Artificial Intelligence Platform and International Business Machines Corp's (NYSE:IBM) WatsonX AI come to mind here.

Defense revenues are expected to jump nearly 10%, with margins climbing from 5.2% to 7.6%. Success will favor those adopting automation and next-generation technologies in this competitive landscape.

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Automation & Onshoring: A Tech Revolution

With the U.S. accelerating its onshoring efforts, automation and AI are emerging as the driving forces powering the shift.

Software companies and data centers are prepping for a revenue surge, with mega-cap tech upping its spending on data centers to $250 billion in 2025.

Robotics and IoT hardware could also rebound from a sales plateau, making the automation sector one to watch. Companies enabling robotics and automation such as Nvidia Corp (NASDAQ:NVDA), Intuitive Surgical (NASDAQ:ISRG), ABB (OTC:ABBNY), Rockwell Automation (NYSE:ROK), Zebra Technologies (NASDAQ:ZBRA), Teradyne (NASDAQ:TER) and UiPath (NYSE:PATH) come to mind.

Energy Independence Goes Nuclear

Energy's next frontier? Nuclear. With mega-cap tech giants eyeing modular nuclear reactors as a green and reliable power source, demand for uranium is heating up. Beyond the U.S., countries like Japan and Germany are also jumping on the nuclear bandwagon, signaling a global shift toward energy resilience.

U.S. companies such as Constellation Energy (NASDAQ:CEG), Cameco (NYSE:CCJ) and NuScale Power (NYSE:SMR) come to mind.

Helfstein's roadmap suggests a year of targeted strategies. By aligning portfolios with these U.S.-centric themes, investors might not just weather volatility—they could thrive in the chaos.

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