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Cognition Therapeutics Announced 95% Reduction of Cognitive Decline in CT1812-treated Patients With Lower Plasma P-tau217 Correlated With Improvements in Key Indicators of Alzheimer's Disease Biology

Cognition Therapeutics Announced 95% Reduction of Cognitive Decline in CT1812-treated Patients With Lower Plasma P-tau217 Correlated With Improvements in Key Indicators of Alzheimer's Disease Biology

Cognition Therapeutics宣佈,在接受CT1812治療的患者中,認知衰退減少了95%,而血漿P-tau217的降低與阿爾茨海默病生物學關鍵因子的改善相關。
Benzinga ·  11/25 20:36

Cognition Therapeutics, Inc., (NASDAQ:CGTX), a clinical-stage company developing drugs to treat neurodegenerative disorders, provided an update on a biomarker(1) analysis from the Phase 2 'SHINE' study in mild-to-moderate Alzheimer's disease. This new analysis focused on plasma samples from all participants who entered the study with lower levels of plasma p-tau217(2) . Several blood-based measures of Alzheimer's disease biology were identified that were normalized in CT1812-treated participants compared to the placebo-treated participants. These biomarker changes occurred in concert with a 95% slowing of cognitive decline as measured by ADAS-Cog11 in the same patients. These data provide further evidence that CT1812 may be preserving cognitive function and slowing disease progression by protecting key neurological system.

Cognition Therapeutics,Inc.(納斯達克:CGTX)是一家臨床階段的公司,致力於開發治療神經退行性疾病的藥物,提供了一份有關在輕至中度阿爾茨海默病的2期'SHINE'研究中生物標誌物分析的更新。這項新分析側重於那些以較低水平的血漿P-τ217進入研究的所有參與者的血漿樣本。發現了幾種阿爾茨海默病生物學的基於血液的測量值,在CT1812治療組與安慰劑治療組相比得到了規範化。這些生物標誌物變化與ADAS-Cog11測量到的同一患者中認知功能衰退減緩95%相一致。這些數據進一步證明了CT1812可能通過保護關鍵的神經系統而維持認知功能並減緩疾病進展。

譯文內容由第三人軟體翻譯。


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