share_log

Children's Hospital of Philadelphia's Center for Data Driven Discovery in Biomedicine Receives Up to $10 Million ARPA-H Award to Create Tool for Sharing Data on Cancer and Rare Diseases

Children's Hospital of Philadelphia's Center for Data Driven Discovery in Biomedicine Receives Up to $10 Million ARPA-H Award to Create Tool for Sharing Data on Cancer and Rare Diseases

費城兒童醫院生物醫學數據驅動發現中心獲得高達1000萬美元ARPA-H獎勵,用於創建用於分享癌症和罕見疾病數據的工具
PR Newswire ·  10/09 22:13

Funded by the Advanced Research Projects Agency for Health, the RADIANT project has the potential to establish a model for control data in clinical trials for difficult-to-treat diseases

由醫學研究先進項目局資助的RADIANt項目有潛力爲難治療疾病的臨床試驗建立一種控制數據模型。

PHILADELPHIA, Oct. 9, 2024 /PRNewswire/ -- A multi-institutional program led by researchers at the Center for Data Driven Discovery in Biomedicine (D3B) at Children's Hospital of Philadelphia (CHOP) has received up to $10 million Advanced Research Projects Agency for Health (APRA-H) Mission Office Innovative Solutions Openings award to research, validate and implement a new model for sharing and integrating data at a national level. This new model is designed to empower research on cancer and other rare diseases in real time, accelerating discoveries and transforming the quality of care for children affected by disease.

PHILADELPHIA,2024年10月9日/ PRNewswire/ - 由費城兒童醫院數據驅動生物醫學發現中心(D3B)的研究人員領導的多機構計劃已獲得高達1000萬美元的醫學研究先進項目局(APRA-H)任務辦公室創新解決方案開放獎勵金,用於研究、驗證和實施一種新的在國家層面分享和整合數據的模型。這種新模型旨在賦予實時對癌症和其他罕見疾病進行研究的能力,加速發現,改善受疾病影響的兒童的護理質量。

The project – Real-time Analysis and Discovery in Integrated And Networked Technologies (RADIANT) – builds upon years of pediatric research at D3B aimed at innovating health care and processing millions of points of data at a larger scale to discover underlying causes of complex cancers and diseases and making those findings rapidly available to researchers and clinicians across the country and the world. The RADIANT project is the first ARPA-H-funded project at CHOP.

該項目 - 實時分析和發現集成和聯網技術(RADIANT)- 延續了D30億在兒科研究上的幾年努力,旨在革新醫療保健並在更大範圍內處理數百萬數據點,以發現複雜癌症和疾病的潛在原因,並迅速將這些發現提供給全國和世界各地的研究人員和臨床醫生。RADIANt項目是費城兒童醫院第一個獲得ARPA-H資助的項目。

"In the setting of pediatric brain tumors and other rare diseases, we often do not have a curative standard of care," said Adam Resnick, PhD, research scientist in the Department of Biomedical and Health Informatics at CHOP and Co-Executive Director of D3B. "As a result, most patients actively participate in a research care model that includes participation in research protocols and clinical trials. Our vision for RADIANT is that clinicians and researchers are able to access real-time data about all patients who might share similarities across different data modalities with any one patient, harnessing cloud-based tools and computation to advance real-time decision making and diagnostics and expedite a patient's access to potential precision medicines and personalized treatments or relevant clinical trials."

"在小兒腦瘤和其他罕見疾病的情況下,我們經常沒有治癒性的標準治療,"費城兒童醫院生物醫學和健康信息學部門的研究科學家、聯合執行董事Adam Resnick博士表示。"結果,大多數患者積極參與研究性護理模式,包括參與研究方案和臨床試驗。我們對RADIANt的願景是,臨床醫生和研究人員能夠訪問所有可能在不同數據模式下與任何患者共享相似性的所有患者的實時數據,利用基於雲的工具和計算促進實時決策和診斷,加速患者獲得潛在的精準藥物和個性化治療或相關臨床試驗。

Expanding on platform tools developed as part of the Gabriella Miller Kids First Data Resource Center and the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Data Hub, the RADIANT project aims to advance new technologies and tools as part of a network architecture that advances the real-time integration of data from a participating patient's electronic health records with genomic and imaging data. With CHOP as the coordination center of the initiative, the goal is to scale linkages across a network of hospitals throughout the nation, sharing critical data and information as well as providing resources for interpreting that data.

作爲加布裏埃拉·米勒兒童優先數據資源中心和INclude(生命週期內共同發生狀況調查,以了解唐氏綜合症E)數據中心開發的平台工具的延展,RADIANt項目旨在推動新技術和工具,作爲網絡架構的一部分,促進來自參與患者電子健康記錄的數據與基因組和影像數據的實時整合。以CHOP作爲這一倡議的協調中心,旨在擴展全國範圍內的醫院網絡之間的聯繫,共享關鍵數據和信息,並提供解釋這些數據的資源。

Researchers at CHOP's D3B will be partnering with other institutions across more than 35 hospitals comprising the Children's Brain Tumor Network (CBTN) and the Pediatric Neuro-Oncology Consortium (PNOC) to develop, deploy, and pilot this groundbreaking resource that advances the interoperability and use of data through platform-enabled standardization and emerging technologies that harness powerful new tools and computational approaches.

CHOP的D30億研究人員將與全國35多家兒童腦腫瘤網絡(CBTN)和兒童神經腫瘤聯盟(PNOC)的其他機構合作,開發、部署和試點這一突破性資源,通過平台實現的標準化和新興技術促進數據的互操作性和使用,利用強大的新工具和計算方法。

"D3B has been able to consistently accelerate discoveries in pediatric cancer, thanks to our focus on big data and the collaborative researchers around the world who utilize our platforms," said Phillip "Jay" Storm, MD, Chief of the Division of Neurosurgery and Co-Director of the Neuroscience Center at CHOP and Co-Executive Director of D3B.data. "This award takes the advancements we've made in the field of pediatric brain tumors and expands them in exciting new directions," "A core tenet of our mission has always been the marriage of research and clinical work, and when fully realized, the work accomplished through this award will transform how bench-to-bedside models of care can improve patients' lives."

「由於我們專注於大數據以及全球合作研究人員利用我們平台,D30億已經能夠在兒童腫瘤領域不斷加速發現,」 CHOP的神經外科部主任、神經科學中心聯席主任,以及D30億數據聯席主任菲利普·「傑伊」·斯托姆博士說道。「這一榮譽將推進我們在兒童腦腫瘤領域取得的進展,引向令人振奮的新方向。」「我們使命的核心理念始終是研究與臨床工作的結合,一旦充分實現,通過這一榮譽所取得的成就將改變基於研究的臨床試驗協調的新模式,並增進通過這些試驗患者對護理的獲取。」

While the initial goals of the RADIANT project will be to use these tools to enhance the precision-based care patients receive while under treatment by their doctor, advancing the research care framework will ultimately inform new models for clinical trial coordination and enhance patient access to care through such trials.

RADIANt項目的最初目標是利用這些工具來增強患者在接受醫生治療時接受的基於精準的護理,推進研究護理框架,最終爲臨床試驗協調製定新模式,並通過此類試驗增進患者對醫療護理的獲取。

"We need to standardize and advance multiple data workflows across institutions in ways that create a unified, real-time view of a patient, combining clinical data workflows with research data from observational and clinical trials," said Sabine Mueller MD, PhD, co-executive chair of CBTN and co-leader of PNOC. "Many pediatric brain tumor patients have no curative standard of care, it's only through advancing new models of care empowered by these technologies that as clinicians we'll be able to enhance options for our patients and their participation in clinical trials."

「我們需要在不同機構之間標準化和推進多個數據工作流程,以創造出患者的統一實時視圖,將臨床數據工作流程與來自觀察性和臨床試驗的研究數據相結合,」 CBTN的聯合執行主席,PNOC的聯合領導者Sabine Mueller博士說道。"許多兒童腦腫瘤患者沒有治癒性的標準護理,只有通過推進這些技術賦能的新護理模式,作爲臨床醫生,我們才能夠爲我們的患者增加選擇,讓他們更多地參與臨床試驗。"

In addition to partnering institutions across CBTN and PNOC, the RADIANT initiative brings together investigators from the Centre Hospitalier Universitaire Sainte-Justine and the HealthShare Exchange (HSX) as well as technology partners including Amazon Web Services, MuleSoft (from Salesforce), Kno2, Peyk, and Flywheel.

除了與CBTN和PNOC的合作機構合作,RADIANt計劃還彙集了來自聖朱斯丁大學醫院和HealthShare Exchange(HSX)以及包括Amazon Web Services、賽富時(MuleSoft)、Kno2、Peyk和Flywheel在內的技術合作夥伴的調查員。

Founded in 2022, the ARPA-H is an agency within the Department of Health and Human Services with a mission of accelerating better health outcomes for everyone by supporting the development of high-impact solutions to society's most challenging health problems. The agency aims to ensure access to solutions regardless of demographics or geography, leveraging diverse perspectives for sustained equity across their policy, practices and programs.

成立於2022年,ARPA-H是衛生與公共服務部內部的機構,旨在通過支持對社會上最具挑戰性的健康問題開發高影響力解決方案來加速所有人的更好健康成果。該機構旨在確保無論人口統計數據或地理位置如何,都能獲得解決方案,利用多元化的觀點促進他們的政策、實踐和項目的持續平等。

This research is supported by ARPA-H under agreement number 140D042490007.

本研究得到ARPA-H在協議編號140D042490007下的支持。

About Children's Hospital of Philadelphia:
A non-profit, charitable organization, Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey, as well as the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia. In addition, its unique family-centered care and public service programs have brought Children's Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit

關於費城兒童醫院:
費城兒童醫院是一家非營利性慈善組織,成立於1855年,是全國第一家兒童醫院。通過長期致力於提供優質患者護理、培訓新一代兒科醫療專業人員並引領重大研究項目,該醫院促成了許多造福全球兒童的發現。其兒科研究項目在全國名列前茅。該機構有着爲兒童提供高級醫療護理的悠久歷史,讓護理更貼近家門口。 CHOP護理網絡,其中包括50多家初級保健機構、專科保健和手術中心、急診護理中心以及賓夕法尼亞州和新澤西州各地的社區醫院聯盟 Middleman家庭館 及其位於普王之王的專門兒童急診部。此外,其獨特的家庭中心護理和公共服務項目使得費城兒童醫院成爲兒童和青少年的主要倡導者。欲了解更多信息,請訪問

Contact: Ben Leach
Children's Hospital of Philadelphia
(609)634-7906
[email protected]

聯繫人:Ben Leach
費城兒童醫院
(609)634-7906
[email protected]

SOURCE Children's Hospital of Philadelphia

賽思嘉利兒童醫院

WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM?

想要您公司的新聞在PRNEWSWIRE.COM上特色呈現嗎?

440k+
440k+

Newsrooms &
新聞發佈室&

Influencers
影響力
9k+
9k+

Digital Media
數字媒體

Outlets
賣場
270k+
270k+

Journalists
新聞記者

Opted In
已選擇加入
GET STARTED
開始使用

譯文內容由第三人軟體翻譯。


以上內容僅用作資訊或教育之目的,不構成與富途相關的任何投資建議。富途竭力但無法保證上述全部內容的真實性、準確性和原創性。
    搶先評論