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Turning Point Therapeutics Announces Management Transition

Turning Point Therapeutics Announces Management Transition

轉折點治療公司宣佈管理層過渡
StreetInsider ·  2020/01/10 06:01

SAN DIEGO, Jan. 09, 2020 (GLOBE NEWSWIRE) -- Turning Point Therapeutics, Inc. (NASDAQ: TPTX), a precision oncology company developing next-generation therapies that target genetic drivers of cancer, today announced that Dr. Jean Cui will step down as the company’s chief scientific officer for family reasons on Jan. 31. Dr. Cui will serve as a consultant and support the company during a transition period until June 30, 2020. She will remain on the company’s board of directors through her current term, which expires at the company’s 2020 annual meeting of stockholders.

聖迭戈,2020年1月9日(環球通訊社)--轉折點治療公司(Turning Point Treeutics,Inc.)納斯達克:多倫多證券交易所(TPTX)),一家開發下一代療法的精確腫瘤學公司目標癌症基因驅動因素研究公司今天宣佈,由於家庭原因,崔順實博士將於1月31日辭去公司首席科學官一職。崔博士將擔任顧問,並在2020年6月30日之前的過渡期內為公司提供支持。她將繼續留在公司董事會,直到她的本屆任期結束,這一任期將在公司2020年年度股東大會上到期。

“We are so grateful to Jean for all she has done as co-founder of the company, and we respect her decision to now prioritize her family’s needs,” said Dr. Athena Countouriotis, president and chief executive officer. “During the past six years, Jean has dedicated herself to building a pipeline of kinase inhibitors with the potential to transform the lives of patients. We are thankful for all she has contributed and proud to carry forward her vision. I will continue to work closely with Jean during this transition period.”

“我們非常感謝瓊作為公司的聯合創始人所做的一切,我們尊重她的決定。現在把家庭需求放在首位,“總裁兼首席執行官雅典娜·康圖裏奧蒂斯博士説。在過去的六年中,Jean一直致力於建立一條激酶抑制劑管道,有可能改變患者的生活。我們感謝她所做的一切,併為實現她的願景而感到自豪。I在這一過渡期內,他將繼續與Jean密切合作。“

Dr. Cui co-founded the company in 2013 to design a platform for the development of tyrosine kinase inhibitors (TKIs) that have the potential to be best-in-class and also overcome resistant mutations emerging following treatment with conventional TKIs. Since then, the company has established a pipeline of three clinical assets in four ongoing clinical studies, including the TRIDENT-1 registrational study of lead drug candidate, repotrectinib.

崔博士於2013年與人共同創立了該公司,旨在設計一個開發酪氨酸激酶抑制劑(TKIs)的平台,這些TKIs有可能成為同類中最好的藥物,還可以克服傳統TKIs治療後出現的耐藥突變。從那時起,該公司已經在四項正在進行的臨牀研究中建立了三項臨牀資產的流水線,其中包括主要候選藥物repotrectinib的三叉戟-1註冊研究。

“With an experienced scientific and development team in place and the advancement of the pipeline programs in their development, the timing is now right for me to step down and focus on priorities for myself and my family,” said Dr. Cui. “I have great confidence in the team led by Athena and look forward to watching the company as it works towards achieving its milestones. It has been a privilege to start the company and I am so proud of what we have built, and all we have accomplished.”

崔博士説:“隨着一支經驗豐富的科研團隊的到位,以及管道項目開發的推進,現在是我辭職的好時機,把重點放在我和我的家人的優先事項上。”“我有很棒的對……有信心這個團隊由雅典娜領導,並期待着觀看該公司朝着實現其里程碑的方向努力。創辦這家公司是一種榮幸,我為我們所建立的以及我們所取得的一切感到自豪。“

About Turning Point Therapeutics Inc.Turning Point Therapeutics is a clinical-stage precision oncology company with a pipeline of internally discovered investigational drugs designed to address key limitations of existing cancer therapies. The company’s lead program, repotrectinib, is a next-generation kinase inhibitor targeting genetic drivers of non-small cell lung cancer and advanced solid tumors. Repotrectinib, which is currently being studied in a registrational Phase 2 study in adults and a Phase 1/2 study in pediatric patients, has shown antitumor activity and durable responses among kinase inhibitor treatment-naïve and pre-treated patients. The company’s pipeline of drug candidates also includes TPX-0022, targeting MET, CSF1R and SRC, which is currently being studied in a Phase 1 trial of patients with advanced or metastatic solid tumors harboring genetic alterations inMET; and TPX-0046, targeting RET and SRC, which is currently being studied in a Phase 1/2 trial of patients with advanced or metastatic solid tumors harboring genetic alterations inRET. Turning Point’s kinase inhibitors are designed to bind to their targets with greater precision and affinity than existing therapies, with a novel, compact structure that has demonstrated an ability to potentially overcome treatment resistance common with other kinase inhibitors. The company is driven to develop therapies that mark a turning point for patients in their cancer treatment. For more information, visitwww.tptherapeutics.com.

關於轉折點治療公司Turning Point Treeutics是一家臨牀階段的精確腫瘤學公司,擁有一系列內部發現的研究藥物,旨在解決現有癌症療法的關鍵侷限性。該公司的主導項目repotrectinib是下一代激酶抑制劑,目標是非小細胞肺癌和晚期實體腫瘤的遺傳驅動因素。Repotrectinib目前正在成人註冊的第2期研究和兒童患者的1/2期研究中進行研究,在激酶抑制劑治療(單純治療和預先治療的患者)中顯示出抗腫瘤活性和持久的反應。該公司的候選藥物還包括針對MET、CSF1R和SRC的TPX-0022,它目前正在對具有INMET基因改變的晚期或轉移性實體腫瘤患者進行第一階段試驗研究;以及TPX-0046,它針對RET和SRC,目前正在對具有RET基因變化的晚期或轉移性實體腫瘤患者進行1/2階段試驗研究。Turning Point的激酶抑制劑被設計成比現有療法更精確和更親和力地結合到它們的靶標上,具有一種新穎、緊湊的結構,已經證明能力有可能克服與其他激酶抑制劑相同的治療耐藥性。該公司被驅使開發標誌着患者癌症治療轉折點的療法。欲瞭解更多信息,請訪問www.tpTreateutics.com。

Forward Looking StatementsStatements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 and include statements regarding the potential of the company’s TKIs to be best in class. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as “plans”, “will”, “believes,” “anticipates,” “expects,” “intends,” “goal,” “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Turning Point Therapeutics’ current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Turning Point Therapeutics’ business in general, and the other risks described in Turning Point Therapeutics’ filings with the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Turning Point Therapeutics undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

前瞻性陳述本新聞稿中包含的有關非歷史事實的陳述屬於1995年“私人證券訴訟改革法”所指的“前瞻性陳述”,其中包括有關該公司的TKI具有成為同類最佳產品的潛力的陳述。由於此類陳述受風險和不確定因素的影響,實際結果可能與此類前瞻性陳述所表達或暗示的結果大不相同。諸如“計劃”、“將”、“相信”、“預期”、“期望”、“打算”、“目標”、“潛在”等詞語以及類似的表述都是為了識別前瞻性陳述。這些前瞻性陳述基於Turning Point Treeutics公司目前的預期,涉及可能永遠不會實現或可能被證明是不正確的假設。由於各種風險和不確定性,實際結果可能與前瞻性陳述中預期的大不相同,這些風險和不確定性包括但不限於風險和不確定性。相聯與Turning Point Treateutics的總體業務有關,以及Turning Point Treateutics向美國證券交易委員會提交的文件中描述的其他風險。本新聞稿中包含的所有前瞻性陳述僅在它們發表之日發表。轉折點治療公司沒有義務更新這些聲明,以反映在聲明發表之日之後發生的事件或存在的情況。

Contact: Jim Mazzolajim.mazzola@tptherapeutics.com858-342-8272

聯繫人:jim Mazzolajim.mazzola@tptherapeutics.com858-342-8272

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譯文內容由第三人軟體翻譯。


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