Calgary, Alberta--(Newsfile Corp. - July 9, 2024) - Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF), and its wholly owned subsidiary, Marvel Biotechnology Inc. (collectively the "Company" or "Marvel"), is pleased to highlight the recently published paper "Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice" by a member of its scientific advisory board, Dr. David Blum and colleagues (PMID 3896478).

In this study, published in the leading neurological journal "Brain", Dr. Blum and colleagues reported that early increases of the adenosine A2A receptor (A2aRs) in brain cells (neurons), can lead to the development of memory loss in mouse models of Alzheimer's. What was notable in this study, was that the memory deficits and behaviour changes in transgenic (APP/PS1) mice were linked to Tau phosphorylation (specifically at the AT8 site), rather than amyloid plaques (the conventional Alzheimer's target).

"The data seems to back up the expression that in Alzheimer's Disease (AD), beta amyloid is the trigger and Tau is the bullet" said Dr. Mark Williams, CSO of Marvel. In recent news, Marvel reported that its lead asset MB204, an A2aR antagonist (which acts against the receptor), decreased Tau phosphorylation (including the AT8 site) in an acute oral study. The mechanism(s) by which MB204 reduces Tau phosphorylation are currently being investigated with Professor Emmanuel Planel, a world leading expert on Tau pathology. Overall, the body of evidence suggests that orally available A2aR antagonists such as MB204 could be a valuable new approach to reducing Tau pathology and treating Alzheimer's cognitive deficits.

About Marvel Biosciences Corp.
Marvel Biosciences Corp., and its wholly owned subsidiary, Marvel Biotechnology Inc., is a Calgary-based pre-clinical stage pharmaceutical development biotechnology company that utilizes a "drug redevelopment" approach to drug development. Historically, when a new class of drug is developed, it is optimized for a particular target, but typically only approved for a specific disease. Often, a new disease is identified which involves the same target, however, pending the remaining patent life, the originally approved drug may not have sufficient time left for it to be commercially viable to be developed for the new disease indication. Marvel develops new synthetic chemical derivatives of the original approved drug for the new disease indication. Patent protection is sought, as the new potential asset is developed by the Company. The Company believes the business model results in significantly less risk, cost and time to develop its assets compared to traditional biotechnology companies.

Marvel Biotechnology Inc. has currently developed several new chemical entities, using synthetic chemical derivatives of known, off-patent drugs, that inhibit the A2a adenosine receptor with application to neurological diseases (depression & anxiety, Alzheimer's, ADHD), and the non-neurological conditions of cancer and non-alcoholic steatohepatitis. Marvel is also exploring additional undisclosed targets to expand its asset pipeline.

Contact Information

Marvel Biosciences Corp.
J. Roderick (Rod) Matheson, Chief Executive Officer or
Dr. Mark Williams, President and Chief Science Officer
Tel: 403 770 2469

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All information contained in this news release with respect to the Company and its subsidiary, (collectively, the "Parties") were supplied by Marvel, respectively, for inclusion herein and each parties' directors and officers have relied on each other for any information concerning such Party.

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