The following is a summary of the Taysha Gene Therapies, Inc. (TSHA) Q1 2024 Earnings Call Transcript:

Financial Performance:

• Taysha Gene Therapies reported Q1 2024 research and development expenses of $20.7 million, seeing a substantial increase from the $12.5 million recorded in Q1 2023, due mainly to the manufacturing process for TSHA-102 and ongoing clinical trial expenses.

• The company's general and administrative expenses were reported to be $7.1 million for Q1 2024, a decrease from $8.8 million in Q1 2023.

• Taysha reported a net loss of $24.1 million or $0.10 per share, in comparison to a net loss of $17.6 million or $0.28 per share in Q1 2023.

• As of March 31, 2024, the company had $124 million in cash and cash equivalents.

• Taysha's current cash resources have been forecasted to support its planned operating expenses and capital requirements into 2026.

Business Progress:

• Taysha has made substantial progress in the development of TSHA-102, their gene therapy program for Rett Syndrome, including encouraging data from the phase I/II REVEAL trial.

• The company has received the Regenerative Medicines Advanced Therapy (RMAT) designation from the FDA, which signals a potential to address unmet needs for such conditions.

• The first patient for the high-dose cohort of their REVEAL Phase I/II trial has been successfully enrolled, with trials expected in Q2 2024. Data from these ongoing trials is expected in mid-2024.

• The company remains focused on advancing their TSHA-102 program, intending to generate critical longer-term clinical data expected to guide the planning of future studies.

• Notably, Taysha has treated two patients with their gene therapy solution, with early reports suggesting positive results. The severity of the disease seems to have little impact on the treatment response.

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