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Azitra Reports Preclinical Data Of ATR-12 And Clinical Design On Netherton Syndrome At ASGCT Annual Meeting

Benzinga ·  May 10 20:04
  • ATR-12 has nanomolar inhibition of key protease in vitro that drives Netherton syndrome
  • Topical application of ATR-12 to ex vivo human skin results in superior LEKTI delivery compared to topical LEKTI application
  • ATR-12 reduces IL-36g, a pro-inflammatory cytokine that drives Netherton syndrome
    • Safe and well tolerated in minipigs
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