Activists in California say they'll submit a proposed ballot measure this week that would legalize the use, production and eventual sales of most psychedelics, including DMT, ibogaine, LSD, mescaline, psilocybin, psilocyn and MDMA. It's the third psychedelics-related initiative that organizers are trying to qualify for next year's ballot after Gov. Gavin Newsom (D) vetoed a psychedelics legalization bill earlier this month.

The proposal, called the Psychedelic Wellness and Healing Initiative of 2024, is relatively permissive: People would no longer face criminal penalties for the use or possession of psychedelics, and they would be able to grow psychedelic...