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Affimed Reports Results for Cancer Therapy in NSCLC Patients

Affimed Reports Results for Cancer Therapy in NSCLC Patients

Affimed報告非小細胞肺癌(NSCLC)患者的癌症治療結果
Benzinga ·  2024/12/17 19:31

Affimed N.V. (NASDAQ:AFMD) ("Affimed," or the "Company"), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, today announced updated clinical data from the ongoing AFM24-102 trial of AFM24/atezolizumab combination therapy in heavily pretreated NSCLC patients. Results continue to demonstrate meaningful clinical activity in both NSCLC EGFRwt and EGFRmut patients with good tolerability. In addition, the Company reported findings from a post-hoc exposure-response analysis in patients treated with 480 mg AFM24 showing higher AFM24 exposure is associated with significantly better response rates, improved PFS and overall survival (OS). Based on these data, the future development program for AFM24 will use a dose of 720 mg weekly, a dose that has already been successfully tested in the phase 1 study of AFM24 showing a manageable safety profile.

Affimed N.V. (納斯達克:AFMD) (「Affimed」或「公司」)是一家臨床階段的免疫腫瘤學公司,致力於讓患者恢復與生俱來的抗擊癌症能力,今天宣佈了正在進行的AFM24-102試驗中AFM24/阿泰珠單抗聯合療法的最新臨床數據,針對重度預處理的非小細胞肺癌(NSCLC)患者。結果繼續顯示在NSCLC EGFRwt和EGFRmut患者中具有重要的臨床活性,且耐受性良好。此外,公司還報告了在接受480 mg AFM24治療的患者中的後驗暴露-反應分析的發現,表明更高的AFM24暴露與顯著更好的反應率、改善的無進展生存期(PFS)和總體生存率(OS)相關。基於這些數據,AFM24的未來開發計劃將使用每週720 mg的劑量,這一劑量在AFM24的一期研究中已成功測試,顯示出可以管理的安全性特徵。

譯文內容由第三人軟體翻譯。


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