NanoViricides Reports Breakthrough in Treating Airborne Viruses, Boosting Lifespan in Infected Mice
NanoViricides Reports Breakthrough in Treating Airborne Viruses, Boosting Lifespan in Infected Mice
NanoViricides, Inc. (NYSE:NNVC) (the "Company"), a global leader in broad-spectrum antiviral nanomedicines, says that the ultra-broad antiviral activity spectrum of NV-387 includes activity against orthopoxvirus family (Smallpox/Mpox), with both inhalation and skin abrasion (sexual) modes of infection acquisition. Ectromelia virus infection of mice is a model for Smallpox infection in humans, and also serves as a surrogate for MPox infection in humans. All three viruses belong to the orthopoxvirus family.
廣譜抗病毒納米藥物領域的全球領導者Nanoviricides, Inc.（紐約證券交易所代碼：NNVC）（“公司”）表示，NV-387 的超寬抗病毒活性譜包括對正痘病毒家族（天花/Mpox）的活性，包括吸入和皮膚磨損（性）感染獲取方式。小鼠的Ectromelia病毒感染是人類天花感染的模型，也是人類mPOx感染的替代品。所有三種病毒都屬於正交病毒家族。
NanoViricides reports that in a lethal animal model of lung infection by Ectromelia virus, oral dosing with NV-387 led to an increase in lifespan of mice that was comparable to oral treatment with tecovirimat (TPOXX, SIGA), the approved drug against Smallpox.
NanoViricides報告說，在Ectromelia病毒肺部感染的致命動物模型中，口服 NV-387 可以延長小鼠的壽命，這與經批准的抗天花葯物tecovirimat（TPOXX，SIGA）的口服治療相當。
This lung infection study substantiates the results of the previously reported intradigital footpad infection study that: (i) NV-387 has comparable antiviral activity as tecovirimat, and
(ii) NV-387 plus tecovirimat has much stronger antiviral activity than either drug alone.
這項肺部感染研究證實了先前報告的數字腳墊感染研究的結果，即：（i）NV-387 具有與 tecovirimat 相當的抗病毒活性，以及
(ii) NV-387 和 tecovirimat 的抗病毒活性比單獨使用任何一種藥物都強得多。
We have completed a lethality animal study wherein animals were infected with ectromelia virus into the lungs directly. In this study, we found that NV-387 alone treated animals survived 15 days, tecovirimat alone treated animals survived 16 days, and NV-387 plus tecovirimat treated animals survived 19 days, whereas vehicle-treated animals died in 8 days.
我們已經完成了一項致死性動物研究，在該研究中，動物被直接感染到肺部的 ectromelia 病毒。在這項研究中，我們發現單獨治療 NV-387 的動物存活了 15 天，單獨治療 tecovirimat 的動物存活了 16 天，經過 NV-387 和 tecovirimat 治療的動物存活了 19 天，而經過載體治療的動物在 8 天內死亡。
This lung-infection study emulates infection from aerosolized dispersion of the virus, as may be expected in a bioterrorism scenario.
這項肺部感染研究模擬了病毒氣溶膠傳播引起的感染，這在生物恐怖主義情景中是可以預料的。
譯文內容由第三人軟體翻譯。