U.S. stocks traded mostly higher, with the Dow Jones index gaining around 80 points on Wednesday.
Shares of Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) fell sharply during Wednesday's session after the company announced a clinical program update for LN-145 TIL therapy in non-small lung cancer (NSCLC).
The FDA placed a clinical hold on the IOV-LUN-202 trial on December 22, 2023, in response to a recently reported Grade 5 (fatal) serious adverse event potentially related to the non-myeloablative lymphodepletion pre-conditioning regimen.
Iovance Biotherapeutics shares dipped 20.4% to $7.07 on Wednesday.
Here are some other big stocks recording gains in today's session.
Nukkleus Inc. (NASDAQ:NUKK) shares declined 28.8% to $2.60 after jumping around 11% on Tuesday.
GreenTree Hospitality Group Ltd. (NYSE:GHG) fell 10% to $3.69.
InnSuites Hospitality Trust (NYSE:IHT) dipped 8.6% to $1.4250.
LanzaTech Global, Inc. (NASDAQ:LNZA) fell 7.6% to $5.00.
Life Time Group Holdings, Inc. (NYSE:LTH) fell 6.9% to $14.30. On Dec 22, Life Time Group Holdings agreed with company's CFO, Robert Houghton that he will resign as CFO.
Cheche Group Inc. (NASDAQ:CCG) fell 6.3% to $6.51.
Canopy Growth Corporation (NASDAQ:CGC) declined 6.2% to $5.31.
Velocity Financial, Inc. (NYSE:VEL) fell 4.8% to $15.62.
The Beauty Health Company (NASDAQ:SKIN) fell 4.8% to $3.0850.
NetEase, Inc. (NASDAQ:NTES) fell 4.2% to $88.30 on continued volatility amid regulatory developments in China's gaming sector.
NIO Inc. (NYSE:NIO) fell 4.1% to $8.95 after rising more than 10% on Tuesday. Nio stock raced higher to start the week after the company launched its new ET9 sedan at its Nio Day event over the weekend.
美國股市大多走高，道瓊斯指數週三上漲約80點。
Iovance Biotherapeutics, Inc.（納斯達克股票代碼：IOVA）的股價在週三的交易中大幅下跌，此前該公司宣佈了非小肺癌（NSCLC）LN-145 TIL療法的臨床項目更新。
美國食品藥品管理局於 2023 年 12 月 22 日暫停 IOV-LUN-202 試驗，以應對最近報告的一起可能與非骨髓消耗性淋巴消耗預處理方案有關的 5 級（致命）嚴重不良事件。
週三，Iovance Biotherapeutics股價下跌20.4％，至7.07美元。
以下是今天交易日其他一些上漲的大型股票。
Nukkleus Inc.（納斯達克股票代碼：NUKK）股價在週二上漲約11％後下跌28.8％，至2.60美元。
格林豪泰酒店集團有限公司（紐約證券交易所代碼：GHG）下跌10％，至3.69美元。
InnSuites Hospitality Trust（紐約證券交易所代碼：IHT）下跌8.6％，至1.4250美元。
LanzaTech Global, Inc.（納斯達克股票代碼：LNZA）下跌7.6％，至5.00美元。
Life Time Group Holdings, Inc.（紐約證券交易所代碼：LTH）下跌6.9％，至14.30美元。12月22日，Life Time Group Holdings與公司首席財務官羅伯特·霍頓達成協議，他將辭去首席財務官一職。
車臣集團公司（納斯達克股票代碼：CCG）下跌6.3％，至6.51美元。
Canopy Growth Corporation（納斯達克股票代碼：CGC）下跌6.2％，至5.31美元。
Velocity Financial, Inc.（紐約證券交易所代碼：VEL）下跌4.8％，至15.62美元。
美容健康公司（納斯達克股票代碼：SKIN）下跌4.8％，至3.0850美元。
由於中國遊戲行業監管的發展，網易公司（納斯達克股票代碼：NTES）下跌4.2％，至88.30美元。
蔚來公司（紐約證券交易所代碼：NIO）在週二上漲超過10％後，下跌4.1％，至8.95美元。蔚來汽車在週末的蔚來日活動中推出了新款ET9轎車後，該公司股價本週開盤走高。
