On June 14, 2024, Invivyd, Inc., a biopharmaceutical company, announced the continued in vitro neutralization activity of its investigational monoclonal antibody (mAb), VYD222 (pemivibart), against the emerging SARS-CoV-2 variants KP.1.1 FLiRT and KP.3. These variants are currently dominant and are predicted by the CDC to become the most prevalent SARS-CoV-2 lineage in the United States. Invivyd's Chief Scientific Officer, Dr. Robert Allen, highlighted the stability of the VYD222 epitope, with a high percentage of sequence conservation observed in 2024. The company's next mAb candidate, VYD2311, also demonstrated continued neutralization activity against these strains. Invivyd uses its proprietary software, VivydTools, to monitor SARS-CoV-2 variants and assess the neutralization efficacy of its mAbs. VYD222, derived from adintrevimab, is being investigated for both the prevention...Show More

On June 14, 2024, Invivyd, Inc., a biopharmaceutical company, announced the continued in vitro neutralization activity of its investigational monoclonal antibody (mAb), VYD222 (pemivibart), against the emerging SARS-CoV-2 variants KP.1.1 FLiRT and KP.3. These variants are currently dominant and are predicted by the CDC to become the most prevalent SARS-CoV-2 lineage in the United States. Invivyd's Chief Scientific Officer, Dr. Robert Allen, highlighted the stability of the VYD222 epitope, with a high percentage of sequence conservation observed in 2024. The company's next mAb candidate, VYD2311, also demonstrated continued neutralization activity against these strains. Invivyd uses its proprietary software, VivydTools, to monitor SARS-CoV-2 variants and assess the neutralization efficacy of its mAbs. VYD222, derived from adintrevimab, is being investigated for both the prevention and treatment of COVID-19 in immunocompromised individuals. Although not yet approved by the FDA or other regulatory authorities, VYD222 has shown promising results against various SARS-CoV-2 variants. Invivyd's INVYMAB™ platform aims to rapidly generate new mAbs to address evolving viral threats. The company has previously received emergency use authorization (EUA) from the FDA for another mAb candidate in March 2024.