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Cognition Therapeutics Announced 95% Reduction of Cognitive Decline in CT1812-treated Patients With Lower Plasma P-tau217 Correlated With Improvements in Key Indicators of Alzheimer's Disease Biology

Benzinga ·  Nov 25 20:36

Cognition Therapeutics, Inc., (NASDAQ:CGTX), a clinical-stage company developing drugs to treat neurodegenerative disorders, provided an update on a biomarker(1) analysis from the Phase 2 'SHINE' study in mild-to-moderate Alzheimer's disease. This new analysis focused on plasma samples from all participants who entered the study with lower levels of plasma p-tau217(2) . Several blood-based measures of Alzheimer's disease biology were identified that were normalized in CT1812-treated participants compared to the placebo-treated participants. These biomarker changes occurred in concert with a 95% slowing of cognitive decline as measured by ADAS-Cog11 in the same patients. These data provide further evidence that CT1812 may be preserving cognitive function and slowing disease progression by protecting key neurological system.

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