Less frequent IV dosing with nemvaleukin in patients with select advanced solid tumors, including ovarian cancer and mucosal melanoma, showed tumor site-specific pharmacodynamic activity and immune activation

Preclinical data demonstrated durable immune responses and tumor growth inhibition with Mural's IL-18 variants, reinforcing pursuit of IND-enabling studies with candidate nomination anticipated by the end of 2024, and IND submission expected in Q4 2025

Additional preclinical data from Mural's IL-12 program suggest the company's approach may unlock the potential of IL-12 as a therapeutic by mitigating the cytokine's historic toxicity; company continues to expect candidate nomination by the end of 2024