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歌礼制药-B(01672.HK):在欧洲肝脏研究学会2024年大会以壁报形式展示正在开展的每日一次ASC41治疗经活检证实的代谢功能障碍相关脂肪性肝炎患者52周II期临床试验的12周积极期中结果

Galena Pharma-B(01672.HK): presented at the 2024 European Liver Association conference in the form of a poster, the 12-week positive results of the ongoing once-daily ASC41 treatment of metabolic dysfunction-related fatty liver disease in 52-week II clini

Gelonghui Finance ·  Jun 11 08:06

On June 11th, Gelon Hui announced that its wholly-owned subsidiary, Ganlei Pharmaceutical Co., Ltd., dedicated to researching, developing, and commercializing new drugs for metabolic dysfunction-associated steatohepatitis (MASH), made a poster presentation at the European Association for the Study of the Liver (EASL) 2024 conference, which was held in Milan, Italy from June 5th to June 8th, 2024.

A poster entitled "ASC41, a selective THRβ agonist, significantly reduces liver fat and alanine aminotransferase (ALT) in MASH patients confirmed by biopsy after 12 weeks of treatment: a mid-term analysis of a 52-week liver biopsy continuous study" showed a clinically significant reduction in liver fat, ALT and aspartate aminotransferase (AST) in biopsy-proven MASH patients after 12 weeks of ASC41 treatment, with the data for ALT and AST distinguishing ASC41 significantly from other thyroid hormone receptor β (THRβ) agonists currently in clinical or commercial stages. In addition, the baseline characteristics of ASC41 (conducted in China) and resmetirom's phase II clinical trial are similar, but ASC41 has a lower body mass index (BMI) and more male participants.

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