The following is a summary of the Panbela Therapeutics, Inc. (PBLA) Q4 2023 Earnings Call Transcript:

Financial Performance:

• Panbela's general and administrative expenses were down to $0.9 million due to lower professional fees.

• Research and development expenses increased to $6.1 million primarily due to increased activity in the ASPIRE trial.

• Net loss for the quarter was $6.5 million, an increase from $4.7 million in the previous year.

• Cash at the end of the quarter was $2.6 million, not including the $9 million from a public offering closed in January.

Business Progress:

• The ASPIRE trial for metastatic pancreatic ductal adenocarcinoma achieved over 50% faster enrollment than projected.

• Plans are underway to advance the FAP program in collaboration with the FDA and EMA.

• The PACES trial cleared a planned futility analysis and completed its enrollment, with data expected by the second half of 2026.

• Panbela divested assets from the Eflornithine Pediatric Neuroblastoma Program, with anticipated non-dilutive payments of up to $9.5 million.

• Panbela has multiple trials in phase 1 and 2 to explore polyamine-targeted therapies in various cancers.

• A collaboration with The Johns Hopkins University School of Medicine for a Phase 1 or Phase 2 program is being planned, with program commencement expected in the first half of the year.

More details: Panbela Therapeutics IR

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