[headline announcement Nuggets]
BeiGene, Ltd. (06160): Baiyueze (Zebutini) was approved for the treatment of chronic lymphoblastic leukemia in the United States.
BeiGene, Ltd. said in a notice that the US Food and Drug Administration (FDA) has approved its Bruton tyrosine kinase (BTK) inhibitor Baiyueze (zebutini) for the treatment of adult patients with chronic lymphoblastic leukemia (CLL) or small lymphocytic lymphoma (SLL).
Baiyueze is designed to achieve targeted and continuous inhibition of BTK protein by optimizing bioavailability, half-life and selectivity. Because of its different pharmacokinetic characteristics from other approved BTK inhibitors, Baiyueze has been shown to inhibit the proliferation of malignant B cells in a number of disease-related tissues.
Comments:BeiGene, Ltd. Co., Ltd. is a commercial biotechnology company specializing in research, development, production and commercialization of innovative drugs. The business covers all over the world. Three products have been approved for sale, including BGB-3111, BGB-A317 and BGB-290. There are also eight products in the clinical stage. The strong growth of the company's Q3 product revenue is mainly due to the improvement of sales of the independently developed cornerstone products Baiyueze and Baize'an.
Of this total, Baiyueze Q3 has global sales of US $155.5 million (+ 136%). Sales in the United States reached $108.1 million (+ 221%), mainly due to the continued growth in the number of prescriptions in the United States and the increased use of clinicians in their approved indications, including mantle cell lymphoma (MCL), Fahrenheit macroglobulinemia (WM) and marginal zone lymphoma (MZL).
Baiyueze has carried out a wide range of global clinical development projects, and has conducted 35 trials in more than 30 regions around the world, with a total of more than 4700 subjects. To date, Baiyueze has been approved in more than 60 markets, including the United States, China, the European Union and Great Britain, Canada, Australia, South Korea, Iceland, Norway and Switzerland.
[key announcement Nuggets]
Geely Automobile (00175): plans to acquire 49.9% stake in Proton and DHG to further strengthen business development in Southeast Asia
Geely Automobile announced that on January 20, 2023, the company's direct wholly-owned subsidiary Linkstate intends to purchase 49.9% of Proton's issued and paid up common shares and sales loans from Geely International Hong Kong at a consideration of RMB 1.063 billion and US $56.39 million (RMB 393.7 million), respectively. The total cash consideration is about 1.4567 billion yuan and the annual interest rate on the sale loan is 6 per cent. As of the date of this announcement, Proton is 50.1% and 49.9% owned by DRBH and Geely International Hong Kong, respectively.
On the same day, Linkstate also entered into the DHG agreement with Geely International Hong Kong, under which Geely International Hong Kong conditionally agreed to sell to Linkstate 49.9% of the issued and fully paid ordinary share capital of DHG for a nominal consideration of US $1.00. As of the date of this announcement, DHG is 50.1% and 49.9% owned by DRBH and Geely International Hong Kong, respectively.
Comments:After experiencing the trough of products in the past three years, Geely has now entered the harvest period of products and technology. Starting in the fourth quarter of this year, Geely will launch a total of 17-18 new models throughout 2023, including fuel (4, such as FX11, Boyue replacement), pure electric (4-5, such as polar krypton MPV EF1E, Geometry A00, etc.) and plug-in (9 models, such as Dihao LP, Xingyue LP and Lecker 01 / 05comp09p, etc.).
Geely's systematic capacity-building of car companies is the most comprehensive, laying a solid foundation for medium-and long-term growth. Including absorbing the systematic R & D, management and manufacturing capabilities established by Volvo; improving brand image through sports cars and luxury cars (Lutes, Volvo, SMART), overseas R & D and manufacturing layout (Volvo, Polar, Proton, CEVT R & D center), as well as intelligent software and hardware advanced integrated layout (ZenseAct, Yigatong, chip, satellite, map, flying car, mobile phone, etc.) and so on.
Proton's main business includes the production and sale of its own-brand motor vehicles in Southeast Asia. The Proton acquisition provides the Group with a valuable opportunity to enter the right-hand-drive passenger car market in Southeast Asia. With Proton's resources and experience, the Group will further strengthen its business development in Southeast Asia.
Yanzhou Mining Energy (01171) made Yingxi, with an expected annual net profit of 30.8 billion yuan, an increase of about 89% over the same period last year.
Yanzhou Mining is expected to achieve a net profit of about 30.6 billion yuan after deducting non-recurring gains and losses belonging to shareholders of listed companies in 2022, an increase of about 14.4 billion yuan or about 89 percent compared with the same period last year.
Comments:Yanzhou Mining Energy Group Co., Ltd. is an international comprehensive energy company based on coal and coal chemical industry in China. The company takes the initiative to adjust the business sector to highlight the main coal industry, and the leading position of coal business is increasingly consolidated. (1) sell Yanzhou Coal International Trading Company and Yanzhou Coal International (Singapore) Co., Ltd., and spin off Wisdom Logistics Company from Yanzhou Mining Energy. (2) divesting the trade of commodities such as electrolytic copper, oil and steel, which has a lower gross profit margin and less cash flow contribution.
In the aspect of coal chemical industry, the company builds "coal-chemical" industry chain, gives full play to the advantages of scale and cost, and creates new profit growth. In 2021, the sales income of chemical products belonging to Lunan Chemical, Future Energy, Yulin Energy and Ordos Energy increased compared with the same period last year, and the total operating income of the company's coal chemical business reached 21.402 billion yuan, an increase of 103.56% over the same period last year. The gross profit per ton in 2021 reached 1305.95 yuan / ton, an increase of 355%.
According to the announcement, the sharp increase in performance over the same period last year is mainly due to the fact that the group's coal prices have remained high since 2022 due to rising energy prices at home and abroad, and the group continues to promote lean management and cost budgeting. Effective control of rising costs and other adverse factors, to achieve a substantial improvement in operating performance.
[list of important announcements for Hong Kong stocks]