Gainers

• Itamar Medical Ltd. (NASDAQ:ITMR) rose 43% to $29.52 in pre-market trading. Zoll Medical said it has signed an agreement to acquire Itamar Medical for $31 per ADS in cash.

• Cyren Ltd. (NASDAQ:CYRN) rose 23.8% to $0.7420 in pre-market trading after jumping over 15% on Friday. Cyren and Improving recently reported a partnership to 'strengthen phishing defense for Microsoft 365.'

• Hepion Pharmaceuticals, Inc. (NASDAQ:HEPA) rose 18.1% to $1.96 in pre-market trading. The company said it expects to release additional data from its Phase 2a ‘AMBITION’ NASH clinical trial today.

• Grupo Financiero Galicia S.A. (NASDAQ:GGAL) shares rose 17.4% to $12.40 in pre-market trading.

• Leap Therapeutics, Inc. (NASDAQ:LPTX) rose 17.1% to $1.71 in pre-market trading after declining around 3% on Friday. Leap Therapeutics, last month, reported a Q2 loss of $0.12 per share.

• Aterian, Inc. (NASDAQ:ATER) rose 13.1% to $13.35 in pre-market trading after gaining over 15% on Friday.

• Document Security Systems, Inc. (NYSE:DSS) rose 11.1% to $1.50 in pre-market trading. Alset Ehome International recently completed a subscription agreement with Document Security Systems.

• Central Puerto S.A. (NYSE:CEPU) rose 11.1% to $3.00 in pre-market trading after declining around 3% on Friday.

• Uranium Royalty Corp. (NASDAQ:UROY) rose 9.7% to $3.84 in pre-market trading after climbing over 10% on Friday.

• Virpax Pharmaceuticals, Inc. (NASDAQ:VRPX) rose 9% to $12.64 in pre-market trading after dipping over 25% on Friday. Virpax Pharmaceuticals filed for offering of 3.4 million shares of common stock.

• Banco Macro S.A. (NYSE:BMA) shares rose 8.3% to $19.80 in pre-market trading. The company, last month, released Q2 results.

• Pampa Energía S.A. (NYSE:PAM) rose 8.1% to $18.00 in pre-market trading. The company released Q2 results last month.

• Aluminum Corporation of China Limited (NYSE:ACH) rose 7.6% to $23.12 in pre-market trading after dropping over 4% on Friday.

• Denison Mines Corp. (NYSE:DNN) rose 5.7% to $1.68 in pre-market trading after gaining over 12% on Friday.

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Check out these big penny stock gainers and losers

Losers

• Farmmi, Inc. (NASDAQ:FAMI) shares fell 36.9% to $0.3629 in pre-market trading after the company reported a proposed underwritten public offering of ordinary shares and pre-funded warrants to purchase ordinary shares. Farmmi’s subsidiary Zhejiang Forest Food Co Ltd recently won a new product order for its dried whole Shiitake mushrooms.

• Valneva SE (NASDAQ:VALN) shares fell 31.5% to $32.07 in pre-market trading after the UK government terminated a supply agreement for the company’s COVID-19 vaccine candidate, VLA2001.

• Dynavax Technologies Corporation (NASDAQ:DVAX) shares fell 14% to $15.10 in pre-market trading after the company issued an update on its COVID-19 collaboration with Valneva.

• U.S. Well Services, Inc. (NASDAQ:USWS) shares fell 13.2% to $0.6585 in pre-market trading after dropping around 4% on Friday. U.S. Well Services, last month, posted a quarterly loss of $0.15 per share.

• China XD Plastics Company Limited (NASDAQ:CXDC) fell 9% to $0.50 in pre-market trading after the company received Nasdaq delisting letter. The company also said it intends to request a hearing before a Nasdaq Hearings Panel.

• Advaxis, Inc. (NASDAQ:ADXS) fell 6.4% to $0.5608 in pre-market trading. Advaxis shares climbed over 28% on Friday after the company reported better-than-expected Q3 earnings results and provided a business update.

• RLX Technology Inc. (NYSE:RLX) fell 6.3% to $5.38 in pre-market trading after dropping around 17% on Friday.